The match will begin at 09.00 pm Pakistan Standard Time (PST).
Islamabad United is at fifth place in the rankings while Quetta Gladiators are third.
The winners of the inaugural edition of the cricket league lost their first match of the campaign to Peshawar Zalmi to 34 runs but made a comeback by ending the unbeaten streak of Multan Sultans, beating the new comers by five wickets.
Quetta Gladiators also got off to a losing start as they were defeated Karachi Kings by 19 runs. The runners up of the 2016 and 2017 edition went on to beat Lahore Qalandars by nine wickets.